Thujaplicin–copper chelates inhibit replication of human influenza viruses
Identifieur interne : 001A44 ( Main/Exploration ); précédent : 001A43; suivant : 001A45Thujaplicin–copper chelates inhibit replication of human influenza viruses
Auteurs : Daisei Miyamoto [Japon] ; Yuki Kusagaya [Japon] ; Naoko Endo [Japon] ; Ayako Sometani [Japon] ; Seiji Takeo [Japon] ; Takashi Suzuki [Japon] ; Yaeno Arima [Japon] ; Katsuyuki Nakajima [États-Unis] ; Yasuo Suzuki [Japon]Source :
- Antiviral Research [ 0166-3542 ] ; 1998.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (), Antiviraux (pharmacologie), Apoptose (), Chiens, Chélateurs (), Cuivre (), Humains, Lignée cellulaire, Monoterpènes, Méthode des plages virales, Réplication virale (), Survie cellulaire (), Tropolone (), Tropolone (analogues et dérivés), Tropolone (pharmacologie), Virus de la grippe A (), Virus de la grippe A (physiologie).
- MESH :
- analogues et dérivés : Tropolone.
- pharmacologie : Antiviraux, Tropolone.
- physiologie : Virus de la grippe A.
- Pascal (Inist)
- Activité biologique, Animaux, Antiviral, Antiviraux, Apoptose, Chien, Chiens, Chélateur, Chélateurs, Cuivre, Cuivre Métal, Humains, In vitro, Infection, Influenzavirus, Lignée MDCK, Lignée cellulaire, Lignée cellulaire établie, Monoterpènes, Mort cellulaire, Méthode des plages virales, Origine végétale, Pharmacognosie, Plante médicinale, Réplication, Réplication virale, Survie cellulaire, Thuja, Thujaplicine, Tropolone, Virus de la grippe A.
- Wicri :
- topic : Plante médicinale.
English descriptors
- KwdEn :
- Animals, Antiviral, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Apoptosis, Apoptosis (drug effects), Biological activity, Cell Line, Cell Survival (drug effects), Cell death, Chelating Agents (chemistry), Chelating agent, Copper (chemistry), Copper Metal, Dog, Dogs, Established cell line, Humans, In vitro, Infection, Influenza A virus (drug effects), Influenza A virus (physiology), Influenzavirus, Medicinal plant, Monoterpenes, Pharmacognosy, Plant origin, Replication, Thuja, Tropolone (analogs & derivatives), Tropolone (chemistry), Tropolone (pharmacology), Viral Plaque Assay, Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Tropolone.
- chemical , chemistry : Antiviral Agents, Chelating Agents, Copper, Tropolone.
- chemical , pharmacology : Antiviral Agents, Tropolone.
- drug effects : Apoptosis, Cell Survival, Influenza A virus, Virus Replication.
- physiology : Influenza A virus.
- Animals, Cell Line, Dogs, Humans, Monoterpenes, Viral Plaque Assay.
- Teeft :
- Anti6iral, Anti6iral research, Apoptosis, Apoptotic, Assay, Canine kidney, Cell death, Cell growth, Cell viability, Chelate, Chem, Copper chelate, Copper chelates, Copper ions, Copper sulfate, Culture medium, Cytometric, Cytometric analysis, Cytotoxic, Cytotoxic effects, Early phase, Early stage, Hela cells, Host cells, Human apoptosis, Inhibitory effects, Lactate dehydrogenase, Mdck, Mdck cells, Metal chelates, Miyamoto, Morphological changes, Postinfection, Supernatant, Suzuki, Takizawa, Test samples, Thuja plicata, Thujaplicin, Thujaplicin copper chelates, Thujaplicins, Total cells, Viral, Viral infection, Virus, Virus infection, Zinc ions.
Abstract
Abstract: The effects of α-, β- and γ-thujaplicins and six of their metal chelates on human influenza virus-induced apoptosis in Madin–Darby canine kidney (MDCK) cells were examined by DNA fragmentation and flow cytometry. Among the compounds tested, thujaplicin–copper chelates inhibited apoptosis induced in the infected MDCK cells with influenza A/PR/8/34(H1N1), A/Shingapol/1/57(H2N2), A/Aichi/2/68(H3N2) and B/Lee/40 viruses, at concentrations of more than 5 μM. These results indicate that the copper chelates inhibit influenza virus-induced apoptosis and that the inhibitory effects may be independent of influenza virus subtype or types. Furthermore, the copper chelates also inhibited the release of the viruses from the infected MDCK cells during apoptosis. The anti-apoptotic effects of the copper chelates may occur 2–4 h postinfection, suggesting that the copper chelates affect MDCK cells directly in the early stage of influenza virus-induced apoptosis. In this study, we demonstrated that thujaplicin–copper chelates inhibit influenza virus-induced apoptosis of MDCK cells and also inhibit virus replication and release from the infected cells.
Url:
DOI: 10.1016/S0166-3542(98)00034-5
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000197
- to stream Istex, to step Curation: 000197
- to stream Istex, to step Checkpoint: 000839
- to stream Main, to step Merge: 001A99
- to stream PascalFrancis, to step Corpus: 000076
- to stream PascalFrancis, to step Curation: 000138
- to stream PascalFrancis, to step Checkpoint: 000076
- to stream Main, to step Merge: 001B74
- to stream PubMed, to step Corpus: 000379
- to stream PubMed, to step Curation: 000379
- to stream PubMed, to step Checkpoint: 000344
- to stream Ncbi, to step Merge: 001376
- to stream Ncbi, to step Curation: 001376
- to stream Ncbi, to step Checkpoint: 001376
- to stream Main, to step Merge: 001A90
- to stream Main, to step Curation: 001A44
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Thujaplicin–copper chelates inhibit replication of human influenza viruses</title><author><name sortKey="Miyamoto, Daisei" sort="Miyamoto, Daisei" uniqKey="Miyamoto D" first="Daisei" last="Miyamoto">Daisei Miyamoto</name></author><author><name sortKey="Kusagaya, Yuki" sort="Kusagaya, Yuki" uniqKey="Kusagaya Y" first="Yuki" last="Kusagaya">Yuki Kusagaya</name></author><author><name sortKey="Endo, Naoko" sort="Endo, Naoko" uniqKey="Endo N" first="Naoko" last="Endo">Naoko Endo</name></author><author><name sortKey="Sometani, Ayako" sort="Sometani, Ayako" uniqKey="Sometani A" first="Ayako" last="Sometani">Ayako Sometani</name></author><author><name sortKey="Seiji Takeo" sort="Seiji Takeo" uniqKey="Seiji Takeo" first="" last="Seiji Takeo">Seiji Takeo</name></author><author><name sortKey="Suzuki, Takashi" sort="Suzuki, Takashi" uniqKey="Suzuki T" first="Takashi" last="Suzuki">Takashi Suzuki</name></author><author><name sortKey="Arima, Yaeno" sort="Arima, Yaeno" uniqKey="Arima Y" first="Yaeno" last="Arima">Yaeno Arima</name></author><author><name sortKey="Nakajima, Katsuyuki" sort="Nakajima, Katsuyuki" uniqKey="Nakajima K" first="Katsuyuki" last="Nakajima">Katsuyuki Nakajima</name></author><author><name sortKey="Yasuo Suzuki" sort="Yasuo Suzuki" uniqKey="Yasuo Suzuki" first="" last="Yasuo Suzuki">Yasuo Suzuki</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:735996364087205C257469F4F7F05747D82AF949</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1016/S0166-3542(98)00034-5</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-2DGLS83N-8/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000197</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000197</idno><idno type="wicri:Area/Istex/Curation">000197</idno><idno type="wicri:Area/Istex/Checkpoint">000839</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000839</idno><idno type="wicri:doubleKey">0166-3542:1998:Miyamoto D:thujaplicin:copper:chelates</idno><idno type="wicri:Area/Main/Merge">001A99</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:99-0041725</idno><idno type="wicri:Area/PascalFrancis/Corpus">000076</idno><idno type="wicri:Area/PascalFrancis/Curation">000138</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000076</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000076</idno><idno type="wicri:doubleKey">0166-3542:1998:Miyamoto D:thujaplicin:copper:chelates</idno><idno type="wicri:Area/Main/Merge">001B74</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:9806486</idno><idno type="wicri:Area/PubMed/Corpus">000379</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000379</idno><idno type="wicri:Area/PubMed/Curation">000379</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000379</idno><idno type="wicri:Area/PubMed/Checkpoint">000344</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000344</idno><idno type="wicri:Area/Ncbi/Merge">001376</idno><idno type="wicri:Area/Ncbi/Curation">001376</idno><idno type="wicri:Area/Ncbi/Checkpoint">001376</idno><idno type="wicri:doubleKey">0166-3542:1998:Miyamoto D:thujaplicin:copper:chelates</idno><idno type="wicri:Area/Main/Merge">001A90</idno><idno type="wicri:Area/Main/Curation">001A44</idno><idno type="wicri:Area/Main/Exploration">001A44</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Thujaplicin–copper chelates inhibit replication of human influenza viruses</title><author><name sortKey="Miyamoto, Daisei" sort="Miyamoto, Daisei" uniqKey="Miyamoto D" first="Daisei" last="Miyamoto">Daisei Miyamoto</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 52-1 Yada, Shizuoka-shi, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Kusagaya, Yuki" sort="Kusagaya, Yuki" uniqKey="Kusagaya Y" first="Yuki" last="Kusagaya">Yuki Kusagaya</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 52-1 Yada, Shizuoka-shi, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Endo, Naoko" sort="Endo, Naoko" uniqKey="Endo N" first="Naoko" last="Endo">Naoko Endo</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 52-1 Yada, Shizuoka-shi, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Sometani, Ayako" sort="Sometani, Ayako" uniqKey="Sometani A" first="Ayako" last="Sometani">Ayako Sometani</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 52-1 Yada, Shizuoka-shi, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Seiji Takeo" sort="Seiji Takeo" uniqKey="Seiji Takeo" first="" last="Seiji Takeo">Seiji Takeo</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 52-1 Yada, Shizuoka-shi, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Suzuki, Takashi" sort="Suzuki, Takashi" uniqKey="Suzuki T" first="Takashi" last="Suzuki">Takashi Suzuki</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 52-1 Yada, Shizuoka-shi, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Arima, Yaeno" sort="Arima, Yaeno" uniqKey="Arima Y" first="Yaeno" last="Arima">Yaeno Arima</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauti-cho, Misasagi, Yamasina-ku, Kyoto 607</wicri:regionArea><wicri:noRegion>Kyoto 607</wicri:noRegion></affiliation></author><author><name sortKey="Nakajima, Katsuyuki" sort="Nakajima, Katsuyuki" uniqKey="Nakajima K" first="Katsuyuki" last="Nakajima">Katsuyuki Nakajima</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Otsuka America Pharmaceutical, Inc., 2440, Research Boulourd, Lock Ville, MD 20850</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Yasuo Suzuki" sort="Yasuo Suzuki" uniqKey="Yasuo Suzuki" first="" last="Yasuo Suzuki">Yasuo Suzuki</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 52-1 Yada, Shizuoka-shi, Shizuoka 422-8526</wicri:regionArea><wicri:noRegion>Shizuoka 422-8526</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Antiviral Research</title><title level="j" type="abbrev">AVR</title><idno type="ISSN">0166-3542</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">39</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="89">89</biblScope><biblScope unit="page" to="100">100</biblScope></imprint><idno type="ISSN">0166-3542</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0166-3542</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Apoptosis</term><term>Apoptosis (drug effects)</term><term>Biological activity</term><term>Cell Line</term><term>Cell Survival (drug effects)</term><term>Cell death</term><term>Chelating Agents (chemistry)</term><term>Chelating agent</term><term>Copper (chemistry)</term><term>Copper Metal</term><term>Dog</term><term>Dogs</term><term>Established cell line</term><term>Humans</term><term>In vitro</term><term>Infection</term><term>Influenza A virus (drug effects)</term><term>Influenza A virus (physiology)</term><term>Influenzavirus</term><term>Medicinal plant</term><term>Monoterpenes</term><term>Pharmacognosy</term><term>Plant origin</term><term>Replication</term><term>Thuja</term><term>Tropolone (analogs & derivatives)</term><term>Tropolone (chemistry)</term><term>Tropolone (pharmacology)</term><term>Viral Plaque Assay</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Apoptose ()</term><term>Chiens</term><term>Chélateurs ()</term><term>Cuivre ()</term><term>Humains</term><term>Lignée cellulaire</term><term>Monoterpènes</term><term>Méthode des plages virales</term><term>Réplication virale ()</term><term>Survie cellulaire ()</term><term>Tropolone ()</term><term>Tropolone (analogues et dérivés)</term><term>Tropolone (pharmacologie)</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Tropolone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Chelating Agents</term><term>Copper</term><term>Tropolone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Tropolone</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Tropolone</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Cell Survival</term><term>Influenza A virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Tropolone</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Dogs</term><term>Humans</term><term>Monoterpenes</term><term>Viral Plaque Assay</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Activité biologique</term><term>Animaux</term><term>Antiviral</term><term>Antiviraux</term><term>Apoptose</term><term>Chien</term><term>Chiens</term><term>Chélateur</term><term>Chélateurs</term><term>Cuivre</term><term>Cuivre Métal</term><term>Humains</term><term>In vitro</term><term>Infection</term><term>Influenzavirus</term><term>Lignée MDCK</term><term>Lignée cellulaire</term><term>Lignée cellulaire établie</term><term>Monoterpènes</term><term>Mort cellulaire</term><term>Méthode des plages virales</term><term>Origine végétale</term><term>Pharmacognosie</term><term>Plante médicinale</term><term>Réplication</term><term>Réplication virale</term><term>Survie cellulaire</term><term>Thuja</term><term>Thujaplicine</term><term>Tropolone</term><term>Virus de la grippe A</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Anti6iral</term><term>Anti6iral research</term><term>Apoptosis</term><term>Apoptotic</term><term>Assay</term><term>Canine kidney</term><term>Cell death</term><term>Cell growth</term><term>Cell viability</term><term>Chelate</term><term>Chem</term><term>Copper chelate</term><term>Copper chelates</term><term>Copper ions</term><term>Copper sulfate</term><term>Culture medium</term><term>Cytometric</term><term>Cytometric analysis</term><term>Cytotoxic</term><term>Cytotoxic effects</term><term>Early phase</term><term>Early stage</term><term>Hela cells</term><term>Host cells</term><term>Human apoptosis</term><term>Inhibitory effects</term><term>Lactate dehydrogenase</term><term>Mdck</term><term>Mdck cells</term><term>Metal chelates</term><term>Miyamoto</term><term>Morphological changes</term><term>Postinfection</term><term>Supernatant</term><term>Suzuki</term><term>Takizawa</term><term>Test samples</term><term>Thuja plicata</term><term>Thujaplicin</term><term>Thujaplicin copper chelates</term><term>Thujaplicins</term><term>Total cells</term><term>Viral</term><term>Viral infection</term><term>Virus</term><term>Virus infection</term><term>Zinc ions</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Plante médicinale</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The effects of α-, β- and γ-thujaplicins and six of their metal chelates on human influenza virus-induced apoptosis in Madin–Darby canine kidney (MDCK) cells were examined by DNA fragmentation and flow cytometry. Among the compounds tested, thujaplicin–copper chelates inhibited apoptosis induced in the infected MDCK cells with influenza A/PR/8/34(H1N1), A/Shingapol/1/57(H2N2), A/Aichi/2/68(H3N2) and B/Lee/40 viruses, at concentrations of more than 5 μM. These results indicate that the copper chelates inhibit influenza virus-induced apoptosis and that the inhibitory effects may be independent of influenza virus subtype or types. Furthermore, the copper chelates also inhibited the release of the viruses from the infected MDCK cells during apoptosis. The anti-apoptotic effects of the copper chelates may occur 2–4 h postinfection, suggesting that the copper chelates affect MDCK cells directly in the early stage of influenza virus-induced apoptosis. In this study, we demonstrated that thujaplicin–copper chelates inhibit influenza virus-induced apoptosis of MDCK cells and also inhibit virus replication and release from the infected cells.</div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="Japon"><noRegion><name sortKey="Miyamoto, Daisei" sort="Miyamoto, Daisei" uniqKey="Miyamoto D" first="Daisei" last="Miyamoto">Daisei Miyamoto</name></noRegion><name sortKey="Arima, Yaeno" sort="Arima, Yaeno" uniqKey="Arima Y" first="Yaeno" last="Arima">Yaeno Arima</name><name sortKey="Endo, Naoko" sort="Endo, Naoko" uniqKey="Endo N" first="Naoko" last="Endo">Naoko Endo</name><name sortKey="Kusagaya, Yuki" sort="Kusagaya, Yuki" uniqKey="Kusagaya Y" first="Yuki" last="Kusagaya">Yuki Kusagaya</name><name sortKey="Seiji Takeo" sort="Seiji Takeo" uniqKey="Seiji Takeo" first="" last="Seiji Takeo">Seiji Takeo</name><name sortKey="Sometani, Ayako" sort="Sometani, Ayako" uniqKey="Sometani A" first="Ayako" last="Sometani">Ayako Sometani</name><name sortKey="Suzuki, Takashi" sort="Suzuki, Takashi" uniqKey="Suzuki T" first="Takashi" last="Suzuki">Takashi Suzuki</name><name sortKey="Yasuo Suzuki" sort="Yasuo Suzuki" uniqKey="Yasuo Suzuki" first="" last="Yasuo Suzuki">Yasuo Suzuki</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Nakajima, Katsuyuki" sort="Nakajima, Katsuyuki" uniqKey="Nakajima K" first="Katsuyuki" last="Nakajima">Katsuyuki Nakajima</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A44 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A44 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:735996364087205C257469F4F7F05747D82AF949
|texte= Thujaplicin–copper chelates inhibit replication of human influenza viruses
}}
| This area was generated with Dilib version V0.6.33. |  |